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Autoimmune

An immune reaction against one's own tissue.  Under normal circumstances, one’s own tissue can be transferred from one place to another without significant problems.  For example, skin from one part of the body can be grafted to another part of the body without being rejected.  This is not the case between siblings or parents.  Through extensive immunological studies, compatibility of those patients can be examined so that in case of necessary transplantation of a vital organ from one organism to the other the degree of immunological reaction and rejection produced by as close a matching as possible. 

The only tissue that will cause an autoimmune reaction and cause the body to form antibodies is the man’s sperm.  If, for one or the other reason, sperm/seminal fluid leaks out of a closely guarded collection and ejaculatory system, it causes formation of antibodies.  These antibodies cause lots of problems, mostly related to ability of the sperm to fertilize the egg.  Leakage of sperm can happen during vasectomy (sterilization of the male by closing/interrupting the vas/ejaculatory route), but also when the vasectomy is repaired by reconnecting the vas, during possible leakage after the reconnecting surgery or trauma to the scrotum/testicles.   The condition sometimes can be treated successfully with high doses of corticosteroids, but such a therapy can cause significant side effects.  Pregnancy can be much more efficiently achieved by in vitro fertilization (IVF), combined with intracytoplasmic sperm injection (ICSI).  Many men who had successful vasectomy prefer in vitro fertilization over vaso-vasostomy/reconnection of the canal.  In these situations, usually only one child is looked for, and if the couple is successful through reversal of previous vasectomy, the question of prevention of unplanned pregnancy becomes difficult to resolve.  Expenses for in vitro fertilization and vaso-vasostomy/reversal of previous sterilization procedure are comparable. 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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Last modified: 07/01/04